Non-coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance

Bone metastases are frequent complications in patients with advanced cancer, which can be fatal or may rapidly impede the quality of life of patients. Current treatments for patients with bone metastases are palliative. Therefore, a better understanding of the molecular mechanisms that precede the overt development of skeletal lesions could lead to better therapeutic interventions. In this review, we present evidence that non-coding RNAs (ncRNAs) such as long ncRNAs, microRNAs, and circular RNAs are emerging as master regulators of bone metastasis formation. We highlight potential opportunities for the therapeutic targeting of ncRNAs. Furthermore, we discuss the possibility that ncRNAs may be used as biomarkers in the context of bone metastases, which might provide insight for improving the response to current bone-targeting therapies.

Automated summary

Bone metastases are common complications in patients with advanced cancer and current treatments are palliative. Research suggests that non-coding RNAs may play a crucial role in bone metastasis formation, offering potential therapeutic targets and biomarkers for improved treatment outcomes.