期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 23, 期 20, 页码 6573-6580出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2015.09.022
关键词
Carbonic anhydrase; Acridine; Sulfonamide; Enzyme inhibition; Isoforms CA I, II, IX and VII
资金
- Dumlupinar University Research Fund [2012-38]
- EU FP7 Project (Dynano)
By using a multi component reaction system (MCR), nitro acridine sulfonamides were obtained from cyclic-1,3-diketones, 4-aminobenzene sulfonamide and aromatic aldehydes. Some novel acridine bis-sulfonamides 6a-l were then synthesized by the reaction between sulfonyl chlorides and the novel amino-acridine sulfonamides 5a and 5b, obtained by reduction of nitro-acridine sulfonamide derivatives 4a and 4b. The newly synthesized compounds were investigated as inhibitors of 4 human carbonic anhydrase isoforms (hCA, EC 4.2.1.1). Several of the compounds showed low micromolar inhibition against the medically relevant isoforms hCA I, II, IX, and XII. (c) 2015 Elsevier Ltd. All rights reserved.
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