期刊
BRAIN STRUCTURE & FUNCTION
卷 224, 期 8, 页码 2757-2774出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-019-01934-5
关键词
Developing inner ear; Otic placode; Neuroblast; Sensory patch; Maculae; Cristae; Otic innervation
资金
- Spanish Ministry of Science [BFU2010-1946]
- Junta de Extremadura [PRE/08031, GR10152, GR15158, IB18046]
- Spanish MICINN [BFU2014-57516P]
- SENECA Foundation [19904/GERM/15]
The inner ear is a complex three-dimensional sensory structure with auditory and vestibular functions. It originates from the otic placode, which generates the sensory elements of the membranous labyrinth and all the ganglionic neuronal precursors. Neuroblast specification is the first cell differentiation event. In the chick, it takes place over a long embryonic period from the early otic cup stage to at least stage HH25. The differentiating ganglionic neurons attain a precise innervation pattern with sensory patches, a process presumably governed by a network of dendritic guidance cues which vary with the local micro-environment. To study the otic neurogenesis and topographically-ordered innervation pattern in birds, a quail-chick chimaeric graft technique was used in accordance with a previously determined fate-map of the otic placode. Each type of graft containing the presumptive domain of topologically-arranged placodal sensory areas was shown to generate neuroblasts. The differentiated grafted neuroblasts established dendritic contacts with a variety of sensory patches. These results strongly suggest that, rather than reverse-pathfinding, the relevant role in otic dendritic process guidance is played by long-range diffusing molecules.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据