期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 82, 期 -, 页码 309-318出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2019.09.001
关键词
High fat diet feeding; Minocycline; Gut microbiome
资金
- Rebecca L. Cooper Medical Research Foundation
- R.D. Wright Biomedical NHMRC [1145634]
- National Health and Medical Research Council of Australia [1145634] Funding Source: NHMRC
An emerging novel therapeutic agent for major depressive disorder, minocycline, has the potential to influence both gut microbiome and inflammatory status. The present study showed that chronic high fat diet feeding led to changes in both behaviour and the gut microbiome in male mice, without an overt inflammatory response. The diet-induced behavioural changes were characterised as increased immobility in the forced swim test and changes in locomotor activities in the open field test. Minocycline significantly altered the gut microbiome, rendering a community distinctly different to both untreated healthy and diet-affected states. In contrast, minocycline did not reverse high fat diet-induced changes in behaviour.
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