期刊
BIOTECHNOLOGY ADVANCES
卷 39, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2019.107442
关键词
Immunoassays; Point-of-care testing (POCT); Lateral flow immunoassay (LFIA); Microfluidic paper-based analytical devices (mu PADs); Nanoparticles
资金
- National Key Research and Development Program of China [2018YFC1707702]
- Key Program for Science and Technology Innovative Research Team in Shaanxi Province of China [2017KCT-22]
- China Postdoctoral Science Foundation [2016M592773]
- Postdoctoral Science Foundation of Shaanxi Province
- Fundamental Research Funds for the Central Universities [PY3A081]
Immunoassay has been routinely used in hospitals and central labs. Nowadays, to further meet the requirement of widespread applications of immunoassays, it is urgently needed to produce a simplified, rapid and low-cost immunoassay to perform tests on site. To this end, paper-based point-of-care (POC) immunoassays have attracted intensive interests in recent years. In this paper, we present a comprehensive review of the recent advances and emerging trends of paper-based POC immunoassays, including the fundamental components and work principles, various detection mechanisms and applications, and existing commercialized devices/products. At last, we envision three promising development directions for paper-based POC immunoassays.
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