期刊
BIOSENSORS & BIOELECTRONICS
卷 141, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2019.111470
关键词
Porphyrinic metal-organic frameworks; Poly(3-methythiophene); Chemical polymerization; Levodopa detection
类别
资金
- National Natural Science Foundation of China [21205103, 21275124]
- Jiangsu Provincial Nature Foundation of China [BK2012258]
- Young and Middle-aged Academic Leaders Foundation of Yangzhou University
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP)
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Porphyrinic Metal-Organic Frameworks (porph-MOFs) are attracting attention due to the redox activity in the porphyrin subunit. Herein, we report the design of a novel core-shell structure hybrid material with a sea-cucumber morphology, namely PMeTh, containing the poly(3-methythiophene) conducting polymer coated on the surface of iron-based porph-MOFs PCN-222(Fe) via in-situ oxidative chemical polymerization. The porous PCN-222(Fe) serves as the electrocatalytic sites, while the poly(3-methythiophene) conducting polymer functions as the charge collector to facilitate the charge transport to the redox active sites. The resulting PMeTh composite demonstrates an excellent electrochemical response towards the levodopa detection. The sensitivity towards the L-dopa detection is estimated to be 1.868 mu A . mu M-1. cm(-2) in the linear concentration of 0.05-7.0 mu mol . L-1 and 0.778 mu A . mu M-1 . cm(-2) in the linear concentration of 7.00-100 mu mol . L-1, respectively. Additionally, the levodopa sensor exhibits a low detection limit of 2 nmol L-1 as well as excellent stability after 120 cycles in 10 mu mol L-1 levodopa. The feasibility of this novel L-dopa sensor was evaluated in human urine samples by standard addition. The satisfactory recoveries were in the range of 97.0-104.5% with the R.S.D. value lower than 4.4%. The method of intergrating porph-MOFs and conducting polymers can efficiently expand the porph-MOFs based composites in bioanalysis.
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