期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 83, 期 12, 页码 2364-2371出版社
OXFORD UNIV PRESS
DOI: 10.1080/09168451.2019.1659721
关键词
Green tea; High-temperature-processed green tea extract (HTP-GTE); gallocatechin gallate (GCG); epigallocatechin gallate (EGCG); cognitive decline
类别
资金
- Amorepacific RD center
Green tea intake is generally recognized as an effective supplement that promotes mental clarity and cognitive function. These health benefits of green tea have been attributed mainly to its effective component, epigallocatechin gallate (EGCG). Because various catechin derivatives potently enhance these health benefits, we manipulated the extraction process with a high-temperature intervention. High-temperature-processed green tea extract (HTP-GTE) showed an elevated proportion of gallocatechin gallate (GCG) content. To investigate the preventive effects of HTP-GTE on cognitive decline, we found its neuroprotective effects against amyloid beta (A beta)-induced neurotoxicity in neurons and clarified that GCG significantly inhibited A beta aggregation in vitro. Moreover, we showed that HTP-GTE intake attenuated several cognitive-decline phenotypes in a model mouse of Alzheimer's disease. These beneficial effects of HTP-GTE against cognitive decline were due to the distinctive composition of the extract and suggest the possibility that HTP-GTE supplementation could attenuate cognitive decline of Alzheimer's disease.
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