期刊
BIOPHYSICAL CHEMISTRY
卷 254, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bpc.2019.106263
关键词
Photosensitization; Membrane photooxidation; Lipid oxidation; Permeability; Membrane domains; Membrane reshaping
资金
- Conselho Nacional de Pesquisa (CNPq) [2016/23071-9, 2014/20107-7]
- Sao Paulo Research Foundation (FAPESP) [2016/23071-9, 2014/20107-7]
- CNPq
In this review, we describe how photooxidation changes membrane properties that can ultimately lead to permanent membrane damage. Lipid photooxidation occurs in the presence of reactive oxygen species such as singlet oxygen and by direct reactions of lipids with a photosensitizer in the excited state. Indeed, lipid oxidation triggers chemical transformations that can alter lipid packing; change the membrane surface area, thickness and elastic modulus; and induce pore formation and phase separation. Here, we highlight how lipid hydroperoxides promote membrane remodelling and phase separation. Further, we emphasize the alterations caused by truncated oxidized lipids that lead to increased membrane permeability. Finally, the consequences of lipid photooxidation on cell functions are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据