期刊
BIOMATERIALS
卷 212, 期 -, 页码 17-27出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.05.007
关键词
Healing markers; Tissue oxygenation; Biocompatible and biodegradable scaffold; Collagen; Dextran; In vivo physiological measurement of oxygenation
资金
- Johns Hopkins University, Applied Physics Laboratory, Research and Exploratory Development Department, Laurel, MD
Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic information. In this study, we developed a collagen-dextran oxygen-sensing biocomposite scaffold membrane in which a phosphorescent oxygen sensor was incorporated to monitor physiological oxygen using in vivo phosphorescence imaging in a preclinical mouse model of wound healing. The oxygen-sensing biocomposite scaffold membrane enabled the noninvasive and longitudinal monitoring of oxygenation changes in vivo in an approach compatible with commercially available preclinical in vivo imaging system instruments. This study provides a new and novel capability where a biocomposite material can serve as a biocompatible, biodegradable theranostic platform to promote and assess tissue oxygenation during wound healing.
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