期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1872, 期 1, 页码 111-121出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2019.06.003
关键词
Cancer; Tumor microenvironment; Cancer-associated fibroblast; Fibroblastic stromal cell; Cancer stem cell; Cancer treatment; Immunotherapy
资金
- Erwin Schrodinger Fellowship [J-3807]
- Austrian Science Fund (FWF)
The functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor microenvironment, cancer-associated fibroblasts take the center stage and fuel tumor progression in various ways including malignant cell potentiation, immune regulation and fibrosis. However, recent studies have demonstrated pronounced heterogeneity of the fibroblastic tumor stroma, which comprises a plethora of individual cell subsets with varying phenotypes and functions, some of which suppress malignant growth through immune engagement or crosstalk with the tumor vasculature. This article summarizes the various levels at which the fibroblastic tumor stroma may impact cancer progression and highlights potential target structures for future therapeutic intervention(s).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据