期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 47, 期 -, 页码 1197-1207出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20190316
关键词
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资金
- Leeds Beckett University fellowship
- BBSRC DTP fellowship [BB/M011151/1]
- BBSRC [BB/M023281/1]
- Academy of Finland [1286429]
- Royal Society Wolfson fellowship
- BBSRC [BB/M021610/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M021610/1] Funding Source: researchfish
Glutamate transporters play important roles in bacteria, archaea and eukaryotes. Their function in the mammalian central nervous system is essential for preventing excitotoxicity, and their dysregulation is implicated in many diseases, such as epilepsy and Alzheimer's. Elucidating their transport mechanism would further the understanding of these transporters and promote drug design as they provide compelling targets for understanding the pathophysiology of diseases and may have a direct role in the treatment of conditions involving glutamate excitotoxicity. This review outlines the insights into the transport cycle, uncoupled chloride conductance and modulation, as well as identifying areas that require further investigation.
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