期刊
BIOCHEMICAL JOURNAL
卷 476, 期 -, 页码 3125-3139出版社
PORTLAND PRESS LTD
DOI: 10.1042/BCJ20190318
关键词
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资金
- Croucher Foundation
- Cambridge Commonwealth, European and International Trust
- Swiss National Science Foundation (SNSF) [P2ZHP2_164947]
- EU H2020 Framework Programme (H2020-MSCA-IF-2017) [789607]
- Bill and Melinda Gates Foundation [SHORTEN-TB OPP1158806]
- National Health and Medical Research Council (Australia) [1016357]
- Swiss National Science Foundation (SNF) [P2ZHP2_164947] Funding Source: Swiss National Science Foundation (SNF)
CoaBC, part of the vital coenzyme A biosynthetic pathway in bacteria, has recently been validated as a promising antimicrobial target. In this work, we employed native ion mobility-mass spectrometry to gain structural insights into the phosphopantothenoylcysteine synthetase domain of E. coli CoaBC. Moreover, native mass spectrometry was validated as a screening tool to identify novel inhibitors of this enzyme, highlighting the utility and versatility of this technique both for structural biology and for drug discovery.
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