期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 516, 期 4, 页码 1090-1096出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2019.06.162
关键词
MoS2 quantum dots; Bottom-up; Fluorescence imaging; In vitro and in vivo
资金
- National Natural Science Foundation of China [81771904, 81874183]
- Natural Science Foundation of Jiangsu Province for the Excellent Young Scholars [BK20170054]
- China Postdoctoral Science Foundation [2016M601890, 177607]
- Qing Lan Project
- Peak of Six Talents of Jiangsu Province [WSN-112]
- Jiangsu Provincial Medical Youth Talent [QNRC2016776]
- Six one project of Jiangsu Province [LGY2018083]
- Xuzhou Science and Technology Project [KC18210]
- Xuzhou Innovation Project [KC16SY153]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18_2194]
Bottom-up method is a popular approach for the preparation of molybdenum disulfide quantum dots (MoS2 QDs) benefitting from less time consumption and no high-powered sonication required. But the relatively low fluorescent quantum yield of the obtained MoS2 QDs and the rare study about their in vivo behavior stimulate us to do more research in this area. In this paper, we proposed a bottom-up hydrothermal method to prepare MoS2 QDs with a quantum yield (QY) of 34.55% by optimizing a series of reaction conditions. The successful fluorescence imaging of tumor cells in vitro and in vivo as well as the systematic in vivo behavior study such as biocompatibility, biodistribution and metabolism route provided the good basis for their wider biomedical applications. (C) 2019 Elsevier Inc. All rights reserved.
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