期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 15, 期 -, 页码 2156-2160出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.15.212
关键词
catalysis; cyclopropanation; indole; norfloxacin quinoline; quinolone; Rh(II); ring expansion
We present a short and efficient way of synthesizing two synthetically versatile 4-quinolone-3-carboxylate building blocks by cyclopropanation-ring expansion of 3-chloroindoles with alpha-halodiazoacetates as the key step. This novel transformation was applied towards the synthesis of the antibiotic drug norfloxacin.
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