期刊
BEHAVIOURAL BRAIN RESEARCH
卷 369, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbr.2019.111922
关键词
Cognition; Emotional behavior; Epileptogenesis; GABA(B) receptor; GINIP; Phf24
资金
- Japan Epilepsy Research Foundation [JERF TENKAN 17004]
Phf24 is known as G alpha i-interacting protein (GINIP) and is associated with the GABA(B) receptor. To study the function of Phf24 protein in the central nervous system (CNS), we have newly developed Phf24-null rats and investigated their behavioral phenotypes, especially changes in seizure sensitivity, emotional responses and cognitive functions. Phf24-null rats did not exhibit any spontaneous seizures. However, they showed a higher sensitivity to pentylenetetrazol (PTZ)- or pilocarpine-induced convulsive seizures. Phf24-null rats also showed an elevated susceptibility to kindling development with repeated PTZ treatments, suggesting that Phf24 acts as an inhibitory modulator in epileptogenesis. Although young Phf24-null rats showed normal gross behaviors, elevated spontaneous locomotor activity, especially in terms of the circadian dark period, emotional hyper-reactivity, reduced anxiety behaviors in the elevated plus-maze (EPM) test, and cognitive deficits in the Morris water maze test were explicitly observed at older age (20-week-old). The present results suggest that Phf24 is essential for proper functioning of the CNS, especially in preventing epileptogenesis and controlling emotional and cognitive functions.
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