The paths of syntheses, chemical characteristics and stability tests for selected synthetic cannabinoids: 5F-PB-22, NM-2201, UR-144, and AB-CHMINACA

This publication describes analytical data for four psychoactive substances: 5F-PB-22, NM-2201, UR-144 and AB-CHMINACA. Compounds were synthesized in our laboratory and their presence was confirmed using electrospray ionisation mass spectrometry (ESI-MS), gas chromatography with electron ionization mass spectrometry detection (GC-EI-MS), gas chromatography with flame ionization detection (GC-FID), high-performance liquid chromatography (HPLC), Raman spectroscopy as well as proton nuclear magnetic resonance (H-1 NMR). Mass spectra show molecular ions and adducts peaks. Characteristic fragmentation patterns for cannabinoids can be seen by referring to GC-EI-MS mass spectra. Simple and sensitive HPLC methods were developed for the qualitative and quantitative determination of all synthesized compounds. RAMAN and GC-FID served as analytical tools for compound identification in the stability test.

Automated summary

This publication presents analytical data for four psychoactive substances, including methods for their synthesis and confirmation such as ESI-MS, GC-EI-MS, GC-FID, HPLC, Raman spectroscopy, and H-1 NMR. It also discusses characteristic fragmentation patterns for cannabinoids and the development of HPLC methods for qualitative and quantitative determination of all synthesized compounds. Additionally, it utilizes RAMAN and GC-FID as analytical tools for compound identification in stability tests.