4.4 Article

The complete genome sequence of the lumpy skin disease virus vaccine Herbivac LS reveals a mutation in the superoxide dismutase gene homolog

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ARCHIVES OF VIROLOGY
卷 164, 期 12, 页码 3107-3109

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SPRINGER WIEN
DOI: 10.1007/s00705-019-04405-8

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  1. National Research Foundation of South Africa [64815] Funding Source: Medline
  2. University of Cape Town [Research Development Grant] Funding Source: Medline

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The lumpy skin disease virus (LSDV) vaccine, Herbivac LS, batch 008, was sequenced and found to differ from the Neethling vaccine strain in the locus encoding a superoxide dismutase (SOD) homolog. The presence of a SOD homolog, be it full-length (as in Herbivac LS) or truncated (as in Neethling) may affect vaccine immunogenicity.

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