期刊
APPLIED SURFACE SCIENCE
卷 489, 期 -, 页码 485-493出版社
ELSEVIER
DOI: 10.1016/j.apsusc.2019.06.054
关键词
Wound healing; Thin films; Growth factors; Alginate; Carboxymethyl cellulose
类别
资金
- Slovenian Research Agency for Research Core Funding [P2-0118, P3-0036, I0-0029, Z2-8168]
The potential of alginate/carboxymethyl cellulose based thin films was demonstrated as a testing platform for evaluation of the influence of in situ incorporated growth factors into formulations intended for 3D bio-printed wound healing materials. Actual formation of blend films with and without included growth factors was analysed using ATR-IR spectroscopy. Surface morphology and topography were evaluated by atomic force and scanning electron microscopies, whereas the hydrophilicity of all tested materials was determined using the water contact angle measurement method. The inclusion of growth factors into blend films did not affect the films' formation, nor their morphology, whereas their highly hydrophilic character was even slightly enhanced by the added growth factors. Further, several aspects (viability, proliferation and cell morphology), in regard to the blend films included growth factors' influence on both of the most abundant skin cell types (keratynocytes and fibroblasts) were tested. A significantly improved cell viability was detected for films with incorporated growth factors. The prepared thin film-based testing platform could present an important tool to aid the development of novel printable (bio)inks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据