期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 63, 期 11, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01373-19
关键词
Escherichia coli; tet(X4); tigecycline resistance; hybrid plasmid
资金
- National Key Research and Development Program of China [2016YFD0501300]
- National Natural Science Foundation of China [31802244]
- Program of Basic Ability Improvement for Young and Middle-Age Teachers in College/University in Guangxi [KY2016YB857]
We reported the complete nucleotide sequence of a tet(X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant Escherichia coli isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a tet(X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids. tet(X4) was flanked by two ISCR2, which may be responsible for tet(X4) mobilization. The occurrence and transmission of this novel hybrid plasmid may exacerbate the spread of the clinically significant tet(X4) gene.
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