期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 63, 期 10, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01186-19
关键词
LuxS/AI-2 system; bacterial resistance; biofilm formation; efflux pump
资金
- Henan University of Science and Technology - National Natural Science Foundation of China [31772761, 31540095]
- Natural Science Foundation of Henan Province [182300410047]
The quorum-sensing (QS) system is an intercellular cell-cell communication mechanism that controls the expression of genes involved in a variety of cellular processes and that plays critical roles in the adaption and survival of bacteria in their environment. The LuxS/AI-2 QS system, which uses AI-2 (autoinducer-2) as a signal molecule, has been identified in both Gram-negative and Gram-positive bacteria. As one of the important global regulatory networks in bacteria, it responds to fluctuations in the numbers of bacteria and regulates the expression of a number of genes, thus affecting cell behavior. We summarize here the known relationships between the LuxS/AI-2 system and drug resistance, discuss the inhibition of LuxS/AI-2 system as an approach to prevent bacterial resistance, and present new strategies for the treatment of drug-resistant pathogens.
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