期刊
ARTHROPOD STRUCTURE & DEVELOPMENT
卷 45, 期 4, 页码 368-379出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.asd.2016.06.002
关键词
Autophagy; Insect midgut; Lepidoptera; Molt; Intestinal stem cells (ISCs)
类别
资金
- FAR (University of Insubria)
The midgut of insects has attracted great attention as a system for studying intestinal stem cells (ISCs) as well as cell death-related processes, such as apoptosis and autophagy. Among insects, Lepidoptera represent a good model to analyze these cells and processes. In particular, larva larva molting is an interesting developmental phase since the larva must deal with nutrient starvation and its organs are subjected to rearrangements due to proliferation and differentiation events. Several studies have analyzed ISCs in vitro and characterized key factors involved in their division and differentiation during molt. However, in vivo studies performed during larva larva transition on these cells, and on the whole midgut epithelium, are fragmentary. In the present study, we analyzed the larval midgut epithelium of the silkworm, Bombyx mori, during larva larva molting, focusing our attention on ISCs. Moreover, we investigated the metabolic changes that occur in the epithelium and evaluated the intervention of autophagy. Our data on ISCs proliferation and differentiation, autophagy activation, and metabolic and functional activities of the midgut cells shed light on the complexity of this organ during the molting phase. (C) 2016 Elsevier Ltd. All rights reserved.
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