期刊
ANALYTICA CHIMICA ACTA
卷 1092, 期 -, 页码 108-116出版社
ELSEVIER
DOI: 10.1016/j.aca.2019.09.051
关键词
Highly reactive oxygen species; Nanoscale metal-organic frameworks; Gold nanoclusters; Cell imaging
资金
- National Key R&D Program of China [2018YFF0215404]
- National Natural Science Foundation of China [11727810, 21606149]
- Shanghai Natural Science Foundation [18ZR1411300]
Nanoscale metal-organic frameworks (NMOFs) have been widely employed in biological diagnosis and treatment system. In this work, glutathione stabilized gold nanoclusters (GSH-AuNCs) were successfully encapsulated in NMOFs and the as-obtained nanocomposites (named as AuNCs@NMOFs) showed nearly 10 times enhancement in fluorescence intensity and longer fluorescence lifetime relative to GSH-AuNCs. In addition, the fluorescence intensity of AuNCs@NMOFs was quenched by highly reactive oxygen species (hROS) due to their strong oxidation ability. Based on the fact, the nanocomposites were used for the detection of hROS with a linear range from 80 nM to 1.0 mu M toward hypochlorite (as the representative of hROS). The limit of detection (LOD) was about 30 nM, which was about 30 times lower than that of GSH-AuNCs (LOD = 0.96 mu M). With the features of good biocompatibility, excellent luminescence and efficient cellular uptake, AuNCs@NMOFs were successfully applied in fluorescence imaging of hROS in living cells. (C) 2019 Elsevier B.V. All rights reserved.
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