期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 20, 期 1, 页码 145-158出版社
WILEY
DOI: 10.1111/ajt.15549
关键词
clinical research; practice; immunosuppression; immune modulation; kidney transplantation; nephrology; microbiomics; tolerance; translational research; science
资金
- CENTAURE foundation
- Roche Organ Transplantation Research Foundation
- European Society for Organ Transplantation grant
- IHU-Cesti project
- French government by National Research Agency via the Investment Into The Future program [ANR-10-IBHU-005]
- Nantes Metropole
- Pays de la Loire Region
- Labex IGO project - Investissements d'Avenir French Government program [ANR-11-LABX-0016-01]
Host-microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age-matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据