期刊
ARQUIVOS DE NEURO-PSIQUIATRIA
卷 74, 期 3, 页码 235-243出版社
ASSOC ARQUIVOS NEURO- PSIQUIATRIA
DOI: 10.1590/0004-282X20160015
关键词
multiple sclerosis; brain atrophy; neurodegeneration
资金
- Merck-Serono Argentina
- Novartis Argentina
- Teva Tuteur
- Merck Serono
- Biogen Idec
- Bayer Schering
- Avanir
- Bayer
- Biogen
- Merck
- Novartis
- Teva
Multiple sclerosis (MS) was always considered as a white matter inflammatory disease. Today, there is an important body of evidence that supports the hypothesis that gray matter involvement and the neurodegenerative mechanism are at least partially independent from inflammation. Gray matter atrophy develops faster than white matter atrophy, and predominates in the initial stages of the disease. The neurodegenerative mechanism creates permanent damage and correlates with physical and cognitive disability. In this review we describe the current available evidence regarding brain atrophy and its consequence in MS patients.
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