期刊
ALCOHOL
卷 82, 期 -, 页码 29-45出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.alcohol.2019.08.003
关键词
Ethanol; Social stress; Adolescence; Corticosterone; Anxiety; Fear conditioning
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Ontario Trillium Scholarship (OTS)
- Ontario Graduate Scholarship (OGS)
- NSERC graduate scholarship
Excessive drinking in adolescence continues to be a problem, and almost a quarter of young Canadians have reported consuming five or more alcoholic drinks in one occasion in recent surveys. The consequences of such drinking may be more pronounced when commenced in adolescence, given the ongoing brain development during this period of life. Here, we investigated the consequences of 3 weeks' intermittent access to ethanol in mid-adolescence to early adulthood in rats, and the extent to which a stress history moderated the negative consequences of ethanol access. In experiment 1, male rats that underwent adolescent social instability stress (SS; daily 1 h isolation + return to unfamiliar cage partner every day from postnatal day [PND] 30-45) did not differ from control (CTL) rats in intake of 10% ethanol sweetened with 0.1% saccharin (access period; PND 47-66). Ethanol drinking reduced proteins relevant for synaptic plasticity (alpha CaMKII, beta CaMKII, and PSD-95) in the dorsal hippocampus, and in CTL rats only in the prefrontal cortex (alpha CaMKII and PSD 95), attenuating the difference between CTL and SS rats in the water-drinking group. In experiment 2, ethanol also attenuated the difference between SS and CTL rats in a social interaction test by reducing social interaction in SS rats; CTL rats, however, had a higher intake of ethanol than did SS rats during the access period. Ethanol drinking reduced baseline and fear recall recovery concentrations of corticosterone relative to those exposed only to water, although there was no effect of either ethanol or stress history on fear conditioning. Ethanol drinking did not influence intake after 9 days of withdrawal; however, ethanol-naive SS rats drank more than did CTL rats when given a 24-h access in adulthood. These results reveal a complex relationship between stress history and ethanol intake in adolescence on outcomes in adulthood. (C) 2019 Elsevier Inc. All rights reserved.
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