期刊
AGING-US
卷 11, 期 18, 页码 7457-7472出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.102253
关键词
interleukin-18; ischemic stroke; association; meta-analysis; cross-sectional study
资金
- Key Science & Technology Project of Shanghai [11411950300]
- National Natural Science Foundation of China [81230027]
- Shanghai Natural Science Foundation [13ZR1460500, 13ZR1409700, 15ZR1412900]
- Shanghai Jiaotong University Medical Engineering Foundation [YG2015MS52, YG2016MS48]
- Innovative research team of high-level local universities in Shanghai
Although interleukin-18 (IL-18) has been implicated in the pathophysiology of stroke, research findings concerning IL-18 level in stroke have been inconsistent. Thus, we performed a cross-sectional study in patients with first-episode ischemic stroke and then extracted relevant data from databases to validate our results. A total of 252 patients and 259 healthy subjects were recruited, and serum IL-18 level was evaluated in a cross-sectional study. Then, we extracted data and conducted a meta-analysis, including 2,928 patients and 3,739 controls to support our results. A 95% confidence interval for standardized mean difference (SMD) was calculated using a Z test. We found IL-18 was higher in stroke patients than in controls (2.39 +/- 0.25 vs. 2.25 +/- 0.28, F=8.60, p=0.004) and was negatively associated with the NIHSS scale (r = -0.14, p=0.028). A subsequent meta-analysis confirmed that IL-18 level was higher in stroke patients than in controls (SMD = 2.14, 95% CI = 1.54 similar to 2.73, P< 0.001). IL-18 level increased with the severity of the stroke (p< 0.01). These findings revealed increased IL-18 level contributed to the development and severity of ischemic stroke, suggesting the potential of this biomarker to become an important reference for the early monitoring of ischemic stroke.
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