期刊
AGEING RESEARCH REVIEWS
卷 53, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2019.05.002
关键词
CKIP-1; Molecular functions; Biological processes; Therapeutic strategies; Intrinsic mechanisms
资金
- China Postdoctoral Science Foundation [2018M640612]
- National Natural Science Foundation of China [81702743, 81570404]
- National Key Technologies R&D Program for New Drugs [2015ZX09J15102]
The casein kinase 2 interacting protein-1 (CKIP-1, also known as PLEKHO1) is initially identified as a specific CK2 alpha subunit-interacting protein. Subsequently, various proteins, including CP alpha, PAK1, Arp2/3, HDAC1, c-Jun, ATM, Smurf1, Rpt6, Akt, IFP35, TRAF6, REG gamma and CARMA1, were reported to interact with CKIP-1. Owing to the great diversity of interacted proteins, CKIP-1 exhibits multiple biologic functions in cell morphology, cell differentiation and cell apoptosis. Besides, these functions are subcellular localization, cell type, and regulatory signaling dependent. CKIP-1 is involved in biological processes consisting of bone formation, tumorigenesis and immune regulation. Importantly, deregulation of CKIP-1 results in osteoporosis, tumor, and atherosclerosis. In this review, we introduce the molecular functions, biological processes and promising of therapeutic strategies. Through summarizing the intrinsic mechanisms, we expect to open new therapeutic avenues for CKIP-1.
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