Copper-Catalyzed Domino Synthesis of Sulfur-Containing Heterocycles Using Carbon Disulfide as a Building Block

In this paper, we describe the successful development of an efficient domino method for the synthesis of C-3 sulfenylated imidazo[1,2-a]pyridine derivatives applying carbon disulfide as a readily available, cheap and easy-to-handle building block. Most importantly, a single copper catalyst mediates two type reactions and three chemical bonds are formed in a one-pot organic transformation. The developed method provids an attractive alternative approach to various potentially bioactive sulfur-containing heterocycles, and will find broad applicability in organic synthesis and pharmaceutical chemistry.