期刊
ADVANCED MATERIALS
卷 32, 期 3, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201806538
关键词
controlled release; functional nucleic acids; sensors and actuators; smart hydrogels and microgels; stimuli-responsive
类别
资金
- National Natural Science Foundation of China [21505078, 21874076]
- Natural Science Foundation of Tianjin City [18JCZDJC37800]
- Fundamental Research Funds for Central Universities (China)
DNA hydrogels, which take advantage of the unique properties of functional DNA motifs, such as specific molecular recognition, programmable and high-precision assembly, multifunctionality, and excellent biocompatibility, have attracted increasing research interest in the past two decades in diverse fields, especially in biosensing and biomedical applications. The responsiveness of smart DNA hydrogels to external stimuli by changing their swelling volume, crosslinking density, and optical or mechanical properties has facilitated the development of DNA-hydrogel-based in vitro biosensing systems and actuators. Furthermore, reducing the sizes of DNA hydrogels to the micro- and nanoscale leads to better responsiveness and delivery capacity, thereby making them excellent candidates for rapid detection, in vivo real-time sensing, and drug release applications. Here, the recent progress in the development of smart DNA hydrogels and DNA microgels for biosensing and biomedical applications is summarized, and the current challenges as well as future prospects are also discussed.
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