期刊
ADVANCED FUNCTIONAL MATERIALS
卷 29, 期 43, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201903860
关键词
aggregation; Fe3O4 nanoparticle; furin; magnetic resonance imaging; tumor
类别
资金
- Ministry of Science and Technology of China [2016YFA0400904]
- National Natural Science Foundation of China [21725505, 81821001, 21675145]
For cancer diagnosis, H-1 magnetic resonance imaging (MRI) is advantageous in sensitivity but lacks selectivity. Endogenous F-19 MRI signal in humans is barely detectable and thus F-19 MRI has very high selectivity. A combination of H-1 and F-19 MRI is ideal for precise tumor imaging but a protease-controlled strategy of simultaneous T-2 H-1 MRI enhancement and F-19 MRI Turn-On has not been reported. Here, used is a click condensation reaction to rationally project a dual-functional fluorine probe 4-(trifluoromethyl)benzoic acid (TFMB)-Arg-Val-Arg-Arg-Cys(StBu)-Lys-CBT (1), which is further utilized to functionalize Fe3O4 nanoparticle (IONP) to achieve IONP@1. As such, the IONP aggregation can be activated by furin addition, thereby enhancing the T-2 H-1 MRI signal and switching the F-19 NMR/MRI signal On. Using this strategy, IONP@1 is successfully applied to detect the activity of the furin enzyme with Turn-On F-19 NMR/MRI and T-2 H-1 MRI signals are enhanced. Moreover, IONP@1 is also applied for precise dual-mode (H-1 and F-19) MR imaging of tumors in zebrafish under 14.1 T. The current approach, therefore, provides a feasible and robust means to reconcile the dilemma between selectivity and sensitivity of conventional MRI probes. More importantly, it is envisioned that, by substituting the TFMB moiety in 1 with a perfluorinated compound, this smart method could be of potential use for precise H-1 MR and F-19 MR imaging of tumor in mouse or in bigger rodents in near future.
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