期刊
ADVANCED FUNCTIONAL MATERIALS
卷 29, 期 46, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201905610
关键词
electrospinning; nanofibrous membranes; protein adsorption; seaweed polysaccharides
类别
资金
- Shandong Provincial Natural Science Foundation [ZR2019YQ19]
- National Natural Science Foundation of China [51403113, 51573080]
- Project of Shandong Province Higher Educational Science and Technology Program [J14LA19]
Construction of simple and efficient protein adsorption materials is extremely vital to satisfy the requirements of highly purified proteins in biopharmaceutical and biotechnological industries, yet remains challenging. Herein, a cost-effective strategy to develop seaweed-derived nanofibrous membranes (NFM) for ultrahigh protein adsorption is reported. Synergistic regulation by cosolvent of ethanol, nonionic surfactants of Triton X-100, and polyethylene oxide (PEO5000k) is employed to realize electrospinning of seaweed-derived sodium alginate (SA) nanofibers with higher alginate content of 98 wt% to date, and following water washing easily generates SA nanofibrous membranes (SA-NFM) with excellent morphology. Benefiting from the nanoscale merit of large specific surface area and tortuously porous microstructure, SA-NFM exhibit a high actual capacity of 1235 mg g(-1) toward lysozyme, which far exceeds maximum value for the reported 2D membrane materials (710 mg g(-1)) and is about 20 times that of commercial membranes adsorbents (51 mg g(-1)). Higher dynamic capacity of 805 mg g(-1) (gravity driven) is also realized to meet the demand of practical application. The SA-NFM also possess outstanding reversibility and unique selectivity toward specific proteins. Herein, SA-NFM represent a perfect candidate for next-generation protein absorbents for fast and efficient bioseparation.
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