期刊
ACTA BIOMATERIALIA
卷 94, 期 -, 页码 11-24出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2019.06.022
关键词
Surface; Protein adsorption; Blood coagulation; Thrombosis; Complement activation; Blood compatibility; Antifouling
资金
- Natural Sciences and Engineering Research Council of Canada
- National Heart, Lung, and Blood Institute, NIH
- National Institute of General Medical Sciences, NIH
- Swedish Research Council (Vetenskapsradet)
The adsorption of proteins is the initiating event in the processes occurring when blood contacts a foreign surface in a medical device, leading inevitably to thrombus formation. Knowledge of protein adsorption in this context has accumulated over many years but remains fragmentary and incomplete. Moreover, the significance and relevance of the information for blood compatibility are not entirely agreed upon in the biomaterials research community. In this review, protein adsorption from blood is discussed under the headings agreed upon and not agreed upon or not known with respect to: protein layer composition, effects on coagulation and complement activation, effects on platelet adhesion and activation, protein conformational change and denaturation, prevention of nonspecific protein adsorption, and controlling/tailoring the protein layer composition. Statement of Significance This paper is part 2 of a series of 4 reviews discussing the problem of biomaterial associated thrombogenicity. The objective was to highlight features of broad agreement and provide commentary on those aspects of the problem that were subject to dispute. We hope that future investigators will update these reviews as new scholarship resolves the uncertainties of today. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据