期刊
ACS NANO
卷 13, 期 11, 页码 12345-12356出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b03912
关键词
hair regeneration; motion-activated device; physical approach; rats and nude mice; growth factors
类别
资金
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01EB021336]
- National Institutes of Health [P30CA014520]
- National Basic Research Program of China (973 Program) [2015CB351905]
Hair loss, a common and distressing symptom, has been plaguing humans. Various pharmacological and non pharmacological treatments have been widely studied to achieve the desired effect for hair regeneration. As a nonpharmacological physical approach, physiologically appropriate alternating electric field plays a key role in the field of regenerative tissue engineering. Here, a universal motion-activated and wearable electric stimulation device that can effectively promote hair regeneration via random body motions was designed. Significantly facilitated hair regeneration results were obtained from Sprague-Dawley rats and nude mice. Higher hair follicle density and longer hair shaft length were observed on Sprague-Dawley rats when the device was employed compared to conventional pharmacological treatments. The device can also improve the secretion of vascular endothelial growth factor and keratinocyte growth factor and thereby alleviate hair keratin disorder, increase the number of hair follicles, and promote hair regeneration on genetically defective nude mice. This work provides an effective hair regeneration strategy in the context of a nonpharmacological self-powered wearable electronic device.
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