期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 40, 页码 37347-37356出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b13874
关键词
gold nanoparticle; hyaluronate; glucose oxidase; nanocomplex; wireless glucose sensor
资金
- Center for Advanced Soft-Electronics (Global Frontier Project) [CASE-2015M3A6A5072945]
- National Research Foundation (NRF) - Ministry of Science and ICT, Korea [2017R1E1A1A03070458]
- World Class 300 Project [S2482887]
- Academic-Industrial Cooperative Establishment Project of the Small and Medium Business Administration (SMBA), Korea [4001811107]
- National Research Foundation of Korea [2017R1E1A1A03070458] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Noninvasive real-time biosensors to measure glucose levels in the body fluids have been widely investigated for continuous glucose monitoring of diabetic patients. However, they suffered from low sensitivity and reproducibility due to the instability of nanomaterials used for glucose biosensors. Here, we developed a hyaluronate-gold nanoparticle/glucose oxidase (HA-AuNP/GOx) complex and an ultralow-power application-specific integrated circuit chip for noninvasive and robust wireless patch type glucose sensors. The HA-AuNP/GOx complex was prepared by the facile conjugation of thiolated HA to AuNPs and the following physical binding of GOx. The wireless glucose sensor exhibited slow water evaporation (0.11 mu L/min), fast response (5 s), high sensitivity (12.37 mu A-dL/mg.cm(2)) and selectivity, a low detection limit (0.5 mg/dL), and highly stable enzymatic activity (similar to 14 days). We successfully demonstrated the strong correlation between glucose concentrations measured by a commercially available blood glucometer and the wireless patch-type glucose sensor. Taken together, we could confirm the feasibility of the wireless patch-type robust glucose sensor for noninvasive and continuous diabetic diagnosis.
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