期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 37, 页码 34196-34202出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b07442
关键词
uric acid; metal-organic frameworks; fluorescent sensor; postsynthetic modification; static quenching mechanism
资金
- State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, China [2019-4]
Uric acid (UA) is a purine metabolite closely related to the metabolic function of human, Fluorescence analysis is a very effective method because of its high selectivity and sensitivity, but it still remains a great challenge for direct UA detection. In this work, a fluorescent sensor based on postfunctionalized metal-organic frameworks (UiO-PSM) was designed focusing on the direct detection of UA. UiO-PSM was synthesized from a zirconium-based metal-organic framework (UiO-66-NH2) and 2-picolinic acid through an amidation reaction. Because UA could quench the fluorescence of UiO-PSM through coordination, hydrogen bonding, and pi-pi interactions, the sensor could detect UA directly. UiO-PSM exhibited the advantages of short reaction time, high selectivity, high sensitivity, and wide linear range for UA detection. This work provided a novel method for UA detection and had potential application values in clinical diagnosis.
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