期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 37, 页码 33628-33636出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b10605
关键词
multistep phototherapy; controllable release; heptamethine cyanine; NIR-activatable; photocleavable linker
资金
- National Natural Science Foundation of China [21574039, 21875063, 81770960]
- Shanghai International Cooperation Program [19440710600]
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20152228]
- Science and Technology Commission of Shanghai [17DZ2260100]
- National Key Research and Development Plan [2018YFC1106100]
The multifunctional effect of a single molecule for therapeutic functionalities on a single theranostic nanosystem has a great significance to enhance the accuracy of diagnosis and improve the efficacy of therapy. Herein, a biocompatible multistep phototherapeutic system (Ppa-Cy7-PEG-biotin) that contains a photosensitizer pyropheophorbide A (Ppa) with the covalent conjunction of a near-infrared (NIR) cyanine dye (Cy7) was successfully fabricated and functionalized with biotin for flexible specific tumor-targeting phototherapy. These theranostic micelles will disaggregate after NIR irradiation via the photodegradation of cyanine accompanied by the photothermal conversion and the optically controlled release for the restoration of photodynamic function of quenched Ppa. Consecutively, promoted treatments of photosensitive molecules greatly prolonged the tumor retention time and treatment efficiency, having a multistep antitumor effect both in vitro and in vivo. Different from the simple phototherapeutic configurations that only act on the superficial areas of tumors at mild doses, the multistep therapy can be competent for broadly damaging the superficial and deeper regions of tumors at the same dose. Therefore, as opposed to the general combination phototherapeutic approach, this strategy presents a photoactivation-based multistep phototheranostic platform with an enormous potential in enhanced combined phototherapy for cancer.
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