期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 36, 页码 32689-32696出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b10237
关键词
amphiphilic polymer; aggregation-induced emission nanoparticle; organophosphorus pesticide; gold nanoparticles; biosensing
资金
- National Natural Science Foundation of China [NSFC: 51733010, 21672267]
- Science and Technology Planning Project of Guangdong [2015B090913003]
- Fundamental Research Funds for the Central Universities
Biosensing applications require signal reporters to be sufficiently stable and biosafe as well as highly efficient. Aggregation-induced emission (AIE) nanoparticles have proven to be capable of cell-imaging and cancer therapy; however, realizing sensitive detection of biomolecules remains a great challenge because of their instability, biotoxicity, and lack of modifiable functional groups. Herein, we report a self-assembling strategy to fabricate AIE nanoparticles (PTDNPs) through the dispersion of amphiphilic polymers (PTDs) in phosphate-buffered saline. The PTDs were prepared through radical copolymerization of N-(1,2,2-triphenylvinyl)-4-acetylaniline and dimethyl diallyl ammonium chloride. We found that the particle size, morphology, functional groups, and fluorescence property of PTDNPs can be fine-tuned. Further, PTDNPs-0.10 were chosen as signal reporters to detect organophosphorus pesticides (OPs) with the aid of gold nanoparticles. Their sensing performance on OPs is superior to that using C-dot/quantum dot/rhodamine B as the signal reporter. This study not only provides new possibilities to fabricate novel AIE nanoparticles with exceptional properties, but also facilitates the AIE nanoparticle's application for target analyte biosensing.
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