期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 36, 页码 32659-32669出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b09824
关键词
gold nanostars; recognition; MRSA; infections; photothermal therapy
资金
- National Natural Science Foundation of China [21807036, 21778020]
- Sci-tech Innovation Foundation of Huazhong Agriculture University [2662017PY042, 2662018PY024]
- Science and Technology Major Project of Guangxi [Gui Ke AA18118046]
The development of new antibacterial agents to deal with the emergence and spread of antibiotic resistance in Gram-positive bacterial pathogens has become an increasing problem. Here, a new strategy is developed for the effective targeting and killing of Gram-positive bacteria based on vancomycin (Van)-modified gold nanostars (AuNSs). Our work has demonstrated that the Van-modified AuNSs (AuNSs@Van) can not only selectively recognize methicillin-resistant Staphylococcus aureus (MRSA) but also kill MRSA under near-infrared laser irradiation in vitro. Additionally, AuNSs@Van shows satisfactory biocompatibility and antibacterial activity in treating bacterial infection in vivo. The attractive trait of AuNSs@Van is attributed to the physical effect of its antibacterial activity, with less potential for resistance development. The aforementioned advantages indicate the potential of AuNSs@Van as a photothermal antibacterial agent for effectively combating Gram-positive bacteria in the field of health care.
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