期刊
NATURE CATALYSIS
卷 2, 期 6, 页码 523-528出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41929-019-0286-7
关键词
-
资金
- analytic department (LIKAT)
- State of Mecklenburg-Western Pomerania
- Federal State of Germany (BMBF)
- EU [670986]
- European Research Council (ERC) [670986] Funding Source: European Research Council (ERC)
The reduction of epoxides has been recognized as an important method for the synthesis of alcohols using stoichiometric amounts of metal hydride reducing agents. However, homogeneous catalysis-enabled hydrogenation processes with molecular hydrogen remain scarce. Here, we present a general methodology for the synthesis of primary alcohols in high yields, selectively and under mild conditions, from aliphatic and aromatic epoxides. Crucial for the hydrogenation of terminal epoxides is the presence of an Fe(BF4)(2)center dot 6H(2)O/tetraphos catalyst system. Compared to existing methods, which make use of noble metals, the presented protocol shows broad substrate scope and good functional group tolerance. The generality of this is showcased by transformation of various natural products, including steroids, terpenoids, sesquiterpenoids and drug derivatives, which give the desired alcohols in moderate to excellent yields. Mechanistic studies confirm the distinct feature of the catalyst system, which is active for Meinwald rearrangement of epoxides as well as for carbonyl hydrogenations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据