期刊
MICROORGANISMS
卷 7, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms7050124
关键词
Streptomyces; polyketides; secondary metabolite; polyketide synthases (PKSs)
类别
资金
- German Federal Ministry of Education and Research (BMBF) under the German-Indonesian anti-infective cooperation (GINAICO) project - German Academic Exchange Service (German: Deutscher Akademischer Austauschdienst or DAAD)
- President's Initiative and Networking Funds of the Helmholtz Association of German Research Centres (German: Helmholtz Gemeinschaft Deutscher Forschungszentren or HGF) [VH-GS-202]
Polyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti-cholesterol, and anti-inflammatory activity. Naturally, they are found in bacteria, fungi, plants, protists, insects, mollusks, and sponges. Streptomyces is a genus of Gram-positive bacteria that has a filamentous form like fungi. This genus is best known as one of the polyketides producers. Some examples of polyketides produced by Streptomyces are rapamycin, oleandomycin, actinorhodin, daunorubicin, and caprazamycin. Biosynthesis of polyketides involves a group of enzyme activities called polyketide synthases (PKSs). There are three types of PKSs (type I, type II, and type III) in Streptomyces responsible for producing polyketides. This paper focuses on the biosynthesis of polyketides in Streptomyces with three structurally-different types of PKSs.
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