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EXPERIMENTAL CELL RESEARCH (2009)
DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif
Jongsun Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
ClipR-59 Interacts with Akt and Regulates Akt Cellular Compartmentalization
Jixin Ding et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Endocytic Accessory Proteins Are Functionally Distinguished by Their Differential Effects on the Maturation of Clathrin-coated Pits
Marcel Mettlen et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Rab GTPases as coordinators of vesicle traffic
Harald Stenmark
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Endocytosis and signalling: intertwining molecular networks
Alexander Sorkin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling
Eva Gonzalez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
Wei-Lei Yang et al.
SCIENCE (2009)
Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes
Maria Yanez-Mo et al.
TRENDS IN CELL BIOLOGY (2009)
Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
Veronique Calleja et al.
PLOS BIOLOGY (2009)
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
Jose Baselga et al.
NATURE REVIEWS CANCER (2009)
Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide
Eric Hajduch et al.
BIOCHEMICAL JOURNAL (2008)
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
Noriko Gotoh
CANCER SCIENCE (2008)
The endosomal protein Appl1 mediates akt substrate specificity and cell survival in vertebrate development
Annette Schenck et al.
CELL (2008)
PTRF-Cavin, a conserved cytoplasmic protein required for Caveola formation and function
Michelle M. Hill et al.
CELL (2008)
Ras nanoclusters: Combining digital and analog signaling
Angus Harding et al.
CELL CYCLE (2008)
Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation
Sara Sigismund et al.
DEVELOPMENTAL CELL (2008)
Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer
Kirstine Roepstorff et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2008)
The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells
Yoko Murayama et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Internalization of EGF Receptor Following Lipid Rafts Disruption in Keratinocytes Is Delayed and Dependent on p38 MAPK Activation
Sylviane Lambert et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression
Rosaline C. -Y. Hui et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
PKBα/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
Lana Bozulic et al.
MOLECULAR CELL (2008)
Scaffolding function of PAK in the PDK1-Akt pathway
Maiko Higuchi et al.
NATURE CELL BIOLOGY (2008)
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
Remi Lasserre et al.
NATURE CHEMICAL BIOLOGY (2008)
The PTEN-PI3K pathway: of feedbacks and cross-talks
A. Carracedo et al.
ONCOGENE (2008)
Nuclear At interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival
Sang Bae Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II
S. Miyamoto et al.
CELL DEATH AND DIFFERENTIATION (2008)
Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration
Miho Takahashi et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Plasma membrane domain organization regulates EGFR signaling in tumor cells
Patrick Lajoie et al.
JOURNAL OF CELL BIOLOGY (2007)
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
Ute Schaeper et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Integrating molecular and network biology to decode endocytosis
Eva M. Schmid et al.
NATURE (2007)
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
Nabil Miled et al.
SCIENCE (2007)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Phosphoinositides: Regulators of membrane traffic and protein function
Michael Krauss et al.
FEBS LETTERS (2007)
Phosphoinositide metabolism during membrane ruffling and macropinosome formation in EGF-stimulated A431 cells
Nobukazu Araki et al.
EXPERIMENTAL CELL RESEARCH (2007)
Role of class II phosphoinositide 3-kinase in cell signalling
M. Falasca et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
Veronique Calleja et al.
PLOS BIOLOGY (2007)
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
John Brognard et al.
MOLECULAR CELL (2007)
Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse
Adriane Regina Todeschini et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
Joffrey Degoutin et al.
FEBS LETTERS (2007)
Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro
Yoshito Takeda et al.
BLOOD (2007)
Do caveolins regulate cells by actions outside of caveolae?
Brian P. Head et al.
TRENDS IN CELL BIOLOGY (2007)
The neck of caveolae is a distinct plasma membrane subdomain that concentrates insulin receptors in 3T3-L1 adipocytes
Michelangelo Foti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Hyperactive Ras in developmental disorders and cancer
Suzanne Schubbert et al.
NATURE REVIEWS CANCER (2007)
Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates CD151-induced endothelial cell proliferation and cell migration
Zhen-Zhong Zheng et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Structural and membrane binding analysis of the phox homology domain of phosphoinositide 3-kinase-C2α
Robert V. Stahelin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Phosphoinositides in cell regulation and membrane dynamics
Gilbert Di Paolo et al.
NATURE (2006)
AKT can be activated in the nucleus
Ruiwen Wang et al.
CELLULAR SIGNALLING (2006)
Structure of the insulin receptor ectodomain reveals a folded-over conformation
Neil M. McKern et al.
NATURE (2006)
Phosphoinositide 3-kinase C2β regulates cytoskeletal organization and cell migration via Rac-dependent mechanism
Roy M. Katso et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
Akira Hayakawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
Anatoly Kiyatkin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
Eleonore Beurel et al.
PROGRESS IN NEUROBIOLOGY (2006)
Identification of a tumour suppressor network opposing nuclear Akt function
Lloyd C. Trotman et al.
NATURE (2006)
A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization
JD Orth et al.
CANCER RESEARCH (2006)
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2α
LJ Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration
Vuk Stambolic et al.
TRENDS IN CELL BIOLOGY (2006)
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
HY Irie et al.
JOURNAL OF CELL BIOLOGY (2005)
Individual phosphoinositide 3-kinase C2α domain activities independently regulate clathrin function
I Gaidarov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The Akt/PKB pathway: molecular target for cancer drug discovery
JQ Cheng et al.
ONCOGENE (2005)
PDGFRαα signaling is regulated through the primary cilium in fibroblasts
L Schneider et al.
CURRENT BIOLOGY (2005)
Rab conversion as a mechanism of progression from early to late endosomes
J Rink et al.
CELL (2005)
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
HW Shin et al.
JOURNAL OF CELL BIOLOGY (2005)
Cerarnide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines
R Goswami et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
The tetraspanin D6.1A and its molecular partners on rat carcinoma cells
C Claas et al.
BIOCHEMICAL JOURNAL (2005)
Rheb binds and regulates the mTOR kinase
X Long et al.
CURRENT BIOLOGY (2005)
PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth
TY Gao et al.
MOLECULAR CELL (2005)
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
MT Kunkel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Activation of Akt-1 (PKB-α) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
JN Hutchinson et al.
CANCER RESEARCH (2004)
SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes
T Sasaoka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells
V Carloni et al.
ONCOGENE (2004)
Role of caveolae and caveolins in health and disease
AW Cohen et al.
PHYSIOLOGICAL REVIEWS (2004)
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
JH Feng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells
E Gonzalez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
N Majewski et al.
MOLECULAR CELL (2004)
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo -: Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
TM Williams et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Common and distinct elements in cellular signaling via EGF and FGF receptors
J Schlessinger
SCIENCE (2004)
The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway
Dawn R. Mattoon et al.
BMC BIOLOGY (2004)
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation
GN Bijur et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Role of caveolin and caveolae in insulin signaling and diabetes
AW Cohen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR
E Odintsova et al.
JOURNAL OF CELL SCIENCE (2003)
RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development
I Adini et al.
GENES & DEVELOPMENT (2003)
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee et al.
CURRENT BIOLOGY (2003)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
GENES & DEVELOPMENT (2003)
Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells
N Patel et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue
AW Cohen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A
LK Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
MP Scheid et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells
G Fiucci et al.
ONCOGENE (2002)
Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae
S Vainio et al.
EMBO REPORTS (2002)
Recruitment of the class II phosphoinositide 3-kinase C2β to the epidermal growth factor receptor:: Role of Grb2
M Wheeler et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
M Drab et al.
SCIENCE (2001)
Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PHC to specific β1 integrins
XA Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade
RM Melillo et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
K Gottlob et al.
GENES & DEVELOPMENT (2001)
Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control
S Parpal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases
LS Lock et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Regulation of macropinocytosis by p21-activated kinase-1
S Dharmawardhane et al.
MOLECULAR BIOLOGY OF THE CELL (2000)
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
CA Baumann et al.
NATURE (2000)
Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1
E Odintsova et al.
CURRENT BIOLOGY (2000)
Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells
WY Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
A Arcaro et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
The class II phosphoinositide 3-kinase PI3K-C2α is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
J Domin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
GA Rodrigues et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
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