期刊
APPLIED MATERIALS TODAY
卷 15, 期 -, 页码 297-304出版社
ELSEVIER
DOI: 10.1016/j.apmt.2019.02.002
关键词
Black phosphorus; Polydopamine; Photoacoustic imaging; Photothermal therapy; Cancer theranostics
资金
- National Natural Science Foundation of China [51573096, 31771036, 51703132, 61435010]
- Basic Research Program of Shenzhen [JCYJ20170412111100742, JCYJ20160422091238319]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
- Science and Technology Development Fund (Macao SAR) [007/2017/A1, 132/2017/A3]
Black phosphorus (BP) is a promising theranostic agent owing to its excellent photothermal property, biocompatibility and biodegradability. However, the rapid degradation of BP with oxygen and moisture causes the innate instability that is the Achilles' heel of BP, hindering its further applications in cancer theranostics. Herein, a facile surface passivation strategy was developed to prepare polydopamine (PDA) coated BP quantum dots (QDs) (denoted as BP@PDA) through self-polymerization method. PDA with enriched phenol groups plays as a scavenger of reactive oxygen, which can efficiently prevent the oxidation of BP quantum dots and make them much stable in water (similar to 90% for BP@PDA vs. only 10% for pure BP QDs after 10 days storage). Furthermore, PDA with strong near-infrared (NIR) absorption could greatly improve the photothermal conversion efficiency (PCE) of BP QDs from 22.6% to 64.2% (similar to 2.84 fold higher). Considering the excellent biodegradability and good biocompability of both BP QDs and PDA, the as-prepared BP@PDA hold great potential for cancer theranostics. (C) 2019 Elsevier Ltd. All rights reserved.
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