期刊
ARCHIVES OF VIROLOGY
卷 161, 期 9, 页码 2575-2579出版社
SPRINGER WIEN
DOI: 10.1007/s00705-016-2937-1
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- USDA's Animal Health and Disease Research Program
- Kansas State Veterinary Diagnostic Laboratory
Metagenomic sequencing of three nasal swabs collected from 10- to 21-day-old pigs exhibiting unexplained acute respiratory disease from two different commercial production facilities in Oklahoma identified a novel genotype of porcine astrovirus 4 (PAstV-4). The genomes had only similar to 75 % nucleotide sequence identity to previously characterized PAstV-4 isolates, while the capsid-encoding ORF2 had only similar to 53 % amino acid sequence identity to reference strains. A TaqMan assay targeting the novel ORF2 gene found 21 % and 19 % incidence in nasal and fecal swabs, respectively, submitted for unrelated diagnostic testing. PAstV-4 RNA levels were significantly higher (P = 0.04) in nasal swabs, suggesting a possible atypical respiratory tropism.
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