期刊
OPEN FORUM INFECTIOUS DISEASES
卷 6, 期 7, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofz255
关键词
bacterial translocation; endotoxin; hepatitis C virus (HCV); macrophage activation
资金
- Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [ZIADK054514, ZIADK075150] Funding Source: NIH RePORTER
Hepatitis C virus (HCV) infects 71 million individuals, and barriers to treatment remain. Bacterial translocation is a complication of chronic HCV infection, and this study evaluated circulating microbial components including lipopolysaccharide, peptidoglycan, and beta-D-glucan in addition to their pattern recognition receptors and degree of hepatic macrophage uptake. The findings suggest that regulation of serum peptidoglycan and beta-D-glucan differs from that of lipopolysaccharide. Additionally, macrophage activation in the liver may be better reflected by the degree of macrophage uptake than by circulating levels of microbial markers. These findings allow for a greater understanding of bacterial translocation and host immune activation during HCV infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据