期刊
CELLS
卷 8, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cells8070714
关键词
circulating tumor cells; hematological cells; neutrophils; platelets; liquid biopsy
类别
资金
- Centre Hospitalier et Universitaire de Nice
- Ligue Departementale de Lutte contre le Cancer des Alpes Maritimes
- Conseil Departemental 06
- Ville de Nice
- Canceropole PACA
- French Government (National Research Agency, ANR) through the Investments for the Future LABEX SIGNALIFE: program [ANR-11-LABX-0028-01]
- CANCAIR GENEXPOSOMICS project
- Region PACA
- Dreal PACA
Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in distant parenchyma. Most of the CTCs released in the blood stream will not resist those challenges and will consequently fail to induce metastasis. A few of them, however, interact closely with other blood cells, such as neutrophils, platelets, and/or macrophages to survive in the blood stream. Recent studies demonstrated that the interaction and modulation of the blood microenvironment by CTCs is pivotal for the development of new metastasis, making it an interesting target for potential novel treatment strategies. This review will discuss the recent research on the processes in the blood microenvironment with CTCs and will outline currently investigated treatment strategies.
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