期刊
CELLS
卷 8, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cells8070670
关键词
inflammatory bowel disease; innervation; nerve stimulation; acetylcholine; norepinephrine
类别
资金
- Galvani Bioelectronics
- KWF Kankerbestrijding (Dutch Cancer Foundation) [10495]
- Medtronic
- Health Holland TKI [LSH16010, LSH17028]
- Horizon 2020 [H2020-MSCA-ITN-2015, H2020-MSCA-ITN-2018]
- Gut Research Services
- Mead Johnsson Nutrition
Inflammatory bowel diseases (IBD) have a complex, multifactorial pathophysiology with an unmet need for effective treatment. This calls for novel strategies to improve disease outcome and quality of life for patients. Increasing evidence suggests that autonomic nerves and neurotransmitters, as well as neuropeptides, modulate the intestinal immune system, and thereby regulate the intestinal inflammatory processes. Although the autonomic nervous system is classically divided in a sympathetic and parasympathetic branch, both play a pivotal role in the crosstalk with the immune system, with the enteric nervous system acting as a potential interface. Pilot clinical trials that employ vagus nerve stimulation to reduce inflammation are met with promising results. In this paper, we review current knowledge on the innervation of the gut, the potential of cholinergic and adrenergic systems to modulate intestinal immunity, and comment on ongoing developments in clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据