期刊
CANCERS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cancers11071022
关键词
hepatocellular carcinoma; platelets; hemostasis; fibrosis; tumor-stroma interactions; hepatic stellate cells; macrophages
类别
资金
- Swedish Cancer Foundation (Cancerfonden) [CAN2017/518, CAN2013/1273]
- Swedish children's cancer foundation (Barncancerfonden)
- Swedish society for medical research (SSMF) [S17-0092]
- O.E. och Edla Johanssons stiftelse
Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in the setting of chronic inflammation and liver damage. The hepatic microenvironment plays a crucial role in the disease development, as players such as hepatic stellate cells, resident liver macrophages (Kupffer cells), endothelial cells, extracellular matrix, and a variety of immune cells interact in highly complex and intertwined signaling pathways. A key factor in these cross-talks are platelets, whose role in cancer has gained growing evidence in recent years. Platelets have been reported to promote HCC cell proliferation and invasion, but their involvement goes beyond the direct effect on tumor cells, as they are known to play a role in pro-fibrinogenic signaling and the hepatic immune response, as well as in mediating interactions between these factors in the stroma. Anti-platelet therapy has been shown to ameliorate liver injury and improve the disease outcome. However, platelets have also been shown to play a crucial role in liver regeneration after organ damage. Therefore, the timing and microenvironmental setting need to be kept in mind when assessing the potential effect and therapeutic value of platelets in the disease progression, while further studies are needed for understanding the role of platelets in patients with HCC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据