期刊
CANCERS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cancers11070934
关键词
cancer stem cells; metastasis; ovarian cancer
类别
资金
- Ovarian Cancer Research Alliance [458788]
- Department of Defense, Defense Health Program Congressionally Directed Medical Research Programs-Ovarian Cancer Research Program [C160425]
Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Cancer stem cells (CSCs) that exist within the bulk tumor survive first-line chemotherapy and contribute to resistant disease with metastasis. Understanding the key features of CSC biology provides valuable opportunities to develop OCSC-directed therapeutics, which will eventually improve the clinical outcomes of patients. Although significant developments have occurred since OCSCs were first described, the involvement of CSCs in ovarian tumor metastasis is not fully understood. Here, we discuss putative CSC markers and the fundamental role of CSCs in facilitating tumor dissemination in OC. Additionally, we focus on promising CSC-targeting strategies in preclinical and clinical studies of OC and discuss potential challenges in CSC research.
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