期刊
EBIOMEDICINE
卷 45, 期 -, 页码 624-629出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2019.06.020
关键词
HIV latency; Shock and kill; HIV reservoirs; Deep latency; Transcription
资金
- Qura Therapeutics [2019-01]
- University of North Carolina at Chapel Hill Center for AIDS Research [P30 AI50410]
Latent HIV reservoir is the main obstacle that prevents a cure for HIV-1 (HIV). While antiretroviral therapy is effective in controlling viral replication, it cannot eliminate latent HIV reservoirs in patients. Several strategies have been proposed to combat HIV latency, including bone marrow transplantation to replace blood cells with CCR5-mutated stem cells, gene editing to disrupt the HIV genome, and Shock and Kill to reactivate latent HIV followed by an immune clearance. However, high risks and limitations to scale-up in clinics, off-target effects in human genomes or failure to reduce reservoir sizes in patients hampered our current efforts to achieve an HIV cure. This necessitates alternative strategies to control the latent HIV reservoirs. This review will discuss an emerging strategy aimed to deeply silence HIV reservoirs, the development of this concept, its potential and caveats for HIV remission/cure, and prospective directions for silencing the latent HIV, thereby preventing viruses from rebound. (C) 2019 University of North Carolina at Chapel Hill. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据