期刊
SCIENCE ADVANCES
卷 5, 期 7, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aav8152
关键词
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资金
- National Research Foundation of Korea (NRF) - Korean government [NRF-2016R1A2B3015840, NRF-2016R1A5A2012284, NRF-2017R1D1B03028379, NRF-2013 R1A4A1069575]
The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)-producing regulatory B (IL-10(+) B-reg) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10(+) B-reg cells are generated and maintained is still very limited. Here, we found that IL-10(+) B-reg cells suppress the activation of IL-13-producing type 2 innate lymphoid cells (IL-13(+)ILC2s) in an IL-10-dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10(+) B-reg cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10(+)B(reg) cells, and IL-13(+)ILC2s in CHS.
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